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Oxidative stress, induced by ROS, triggered the translocation of Fas into lipid rafts, the formation of a Fas-associated signaling complex, and the subsequent activation of caspases-8 and -3

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Thus, both CI and CII exhibited a significant lower activity, which was confirmed by a lower state apparent upon Gclc ablation (Supplementary Fig

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Frequent loss of heterozygosity (LOH) on chromosome 3p in lung tumors was associated with low GPx1 enzyme activities, which may affect the prognosis of lung cancer patients [86]

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75 In summary, we conclude that NBDHEX and its analogs may serve as potential treatment strategies in the management of patients with melanoma

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