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In the SURMOUNT-1 trial, Tirzepatide produced average weight reductions of 15.0%, 19.5%, and 20.9% at weekly doses of 5 mg, 10 mg, and 15 mg respectively, over 72 weeks (Jastreboff et al., NEJM 2022
the compound class is promising as a research platform for metabolic-disease biology and combinatorial strategies with diet or NAD precursor approaches
Metabolic heterogeneity of activated beige/brite adipocytes in inguinal adipose tissue
To put the truth into perspective, its been comprehensively looked at in a David McAuley article in Global RPh, which is aimed at helping physicians, clinical researchers, and healthcare professionals understand the risks of this stack