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Conclusions In this study, we developed and validated a novel, label-free HPLC-MS/MS method for the comprehensive, simultaneous quantification of 21 key metabolites involved in glutathione and sulfur metabolism

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Patients with diabetic retinopathy, diabetic neuropathy, and both diabetes and hyperlipidemia had a significantly lower total and free carnitine level compared with the diabetic patients without complications or co-morbidities