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An animal model found that giving d-alpha-tocopherol, a form of vitamin E, to rats 24 hours before a high dose of doxorubicin reduced cardiotoxicity without interfering with the chemotherapeutic effects of doxorubicin on leukemia (Sonneveld 1978)

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1 - 13 We recently reviewed its significance 1 - 13 as a likely mediator of the Roberts stomach cytoprotection/adaptive cytoprotection 14 - 19 and organoprotection, 20 , 21 as well as a novel mediator of the Selyes stress coping response, 22 - 25 generally known, but still not completely clarified