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Theoretically, the accumulation of unfolded proteins in the ER can cause ER stress and lead to unfolded protein response 44

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In cancer cells, iron can be internalized by endocytosis 6,24 and regulates cell-state transitions and cell proliferation 6,25

A1298C Mutation: This mutation involves a change at position 1298 in the MTHFR gene, where adenine (A) is replaced by cytosine (C)

When to Seek Medical Advice About B12 and Liver Health If you have been diagnosed with fatty liver disease and subsequent blood tests reveal elevated B12 levels, it is important to discuss these findings with your GP or hepatologist