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MECHANISM CATEGORIES RESEARCH CONDITIONS SAFETY Side effects Nausea (dose-dependent) Vomiting Diarrhea Constipation Injection-site reactions Resting heart-rate increase Known interactions Other GLP-1R agonists (concurrent use not studied) Insulin / sulfonylureas (hypoglycemia risk) Contraindications Personal/family history of medullary thyroid carcinoma (class-based caution) Multiple endocrine neoplasia type 2 REGULATORY STATUS FDA Investigational compound NOT FDA-approved TRIUMPH Phase 3 program ongoing as of 2026-05

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