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Mental health changes: Semaglutide may cause sudden changes in mood, behavior, or emotional state

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Swollen lymph nodes occurring during GLP-1 therapy typically have alternative causes requiring appropriate clinical evaluation

Clinical trials and meta-analyses consistently show that DPP-4 inhibitors produce a modest but clinically meaningful reduction in HbA1c , typically in the range of: 0.5% to 1.0% (approximately 5.5 to 11 mmol/mol) when used as monotherapy or add-on therapy Reductions at the higher end of this range are more likely when baseline HbA1c is significantly elevated For example, sitagliptin has demonstrated reductions of around 0.60.8% in randomised controlled trials, while vildagliptin and saxagliptin show broadly comparable efficacy

The FDA notes permanent scarring, serious infections, skin deformities, cysts, and deep painful knots in patients who received unapproved fat dissolving injections