GLP-1 is a naturally occurring hormone that influences our blood sugar levels, insulin levels, and feelings of hunger
Notably, GLP-1/GIP dual agonists like tirzepatide demonstrated superior safety profiles in several categories, including lower rates of neoplasms (abnormal tissue growth) compared to single-action GLP-1 medications
In humans, GLP-1Rs are found in a variety of tissues, including pancreatic islets, the lungs, the kidneys, the gastrointestinal tract, the central nervous system, the vagus nerve, endothelial cells and smooth muscle cells, as well as in atrial and ventricular cardiomyocytes
Lastly, in markets where appropriate, insurers can also engage with pharmaceutical companies or pharmacy supply chains to ensure optimal pricing and value for the drug
These findings add to a growing body of anecdotal and pharmacovigilance data suggesting that clinicians and patients should be aware of these unusual neurological reactions