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Safety Considerations for Older Adults Using Weight Loss Injections Older adults face heightened risks from GLP-1 receptor agonists, including dehydration from gastrointestinal side effects, accelerated sarcopenia from rapid weight loss, increased hypoglycaemia risk with concurrent diabetes medications, and greater susceptibility to drug interactions due to polypharmacy

GLP-1 receptor agonists reduce energy intake by up to roughly 40%, according to a 2025 review of the evidence, and they do it through three overlapping pathways: appetite suppression, delayed gastric emptying, and altered nutrient absorption

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Metabolic disorders

The 2024 average AOM semaglutide prescription rate was 23.7-fold higher than the AOM liraglutide prescription rate