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Clinicians may accelerate titration due to patient demand for faster weight loss or improved glucose control

Higher body mass dilutes the per-kilogram dose, which can reduce both the effects and side effects at lower dose levels

Increased alpha 2-adrenergic binding sites and antilipolytic effect in adipocytes from genetically obese rats

This slower digestion increases feelings of fullness and satiety, helping to naturally reduce appetite and caloric intake

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