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Impaired astrocyte function can result in decreased elimination of extracellular glutamate, leading to a reduced seizure threshold and an imbalance between neuronal excitation and inhibition (Bialer & White, 2010)

The murine ALL was transplanted into C57BL/6 mice

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In vitro data suggest that the primary route of metabolism of empagliflozin in humans is glucuronidation by the uridine 5'-diphospho-glucuronosyltransferases UGT1A3, UGT1A8, UGT1A9, and UGT2B7

United States 2007 - Balzan Prize (International Balzan Foundation)