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Preliminary evidence to support the effect of metformin was collected from the preclinical and observational studies, but the drug is now also being tried in various clinical trials to prove its potential in chronic human diseases

Clinical data from GLP-1 trials paints a concerning picture for those prioritizing body composition

Some patients respond better to alternative GLP-1 compounds like tirzepatide, which activates both GLP-1 and GIP receptors for broader appetite suppression

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All GLP-1 receptor agonists and tirzepatide carry a boxed warning about thyroid C-cell tumors seen in rodent studies and are contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)