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This low efficacy may be due to the poor solubility of hydrophobic CPPs 61

GPx2 is expressed predominantly in the gastrointestinal tract and is considered the first protective barrier against the absorption of hydroperoxides from processed food

At the end of the 36-week open-label lead-in period on tirzepatide 10 mg or 15 mg, subjects experienced an average weight reduction of -20.9%

In Phase 3 trials, about 25% of women on Vyleesi had a meaningful increase in their desire score (measured by a validated Female Sexual Function Index domain) compared to ~17% on placebo, and similarly saw a reduction in sexual distress

Cell 11 , 2533 (2003)