Vomiting occurs in roughly 25% of participants
The Timeline: How Plasma Glutathione Levels Decline After Stopping Plasma glutathione follows a biphasic elimination curve after supplementation stops
In the last few years, various GSH modulation-enhanced combinational therapy strategies have been extensively exploited, accompanied by the development of versatile metal-based nanosystems with different structures, functionalities, and treatment performances ( In view of the rapid development of GSH-responsive and -exhausting metal nanomedicines in potentiating cancer therapy, we summarize and outline the recent advancements, mechanisms, prospects, and challenges in this field from different strategies (Scheme 1)
Franco R, Schoneveld OJ, Pappa A, Panayiotidis MI
32 Efflux lowers the intracellular drug concentration below inhibitory levels