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A series of transporters primarily acting in the kidney is responsible for the control of UA in the blood 3 , with URAT1 (coded by SLC22A12) responsible for most kidney reabsorption into the blood and ABCG2 (or breast cancer resistance protein, BCRP) mainly involved in secretion into urine

When Yuyang Liu, a graduate student in his lab and first author of the study, compared SLC25A39's structure against others in the SLC family of transporters in the AlphaFold protein structure database, Liu spotted a unique extra loop in the protein

PubMed, Minalyan, Artem, et al

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Right upper quadrant pain, fever, jaundice, or dark urine could indicate gallbladder problems and require immediate attention