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[2] IGF-1 LR3, by contrast, is an entirely artificial construct designed in a laboratory to solve a specific pharmacological problem: the rapid inactivation of IGF-1 by its binding proteins

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Biol Neonate 85 : 188194 Manzella D, Grella R, Esposito K, Cacciapuoti F, Arciello A, Giugliano D, Paolisso G 2005 Oral amino acid administration decreases oxidative stress and improves brachial reactivity in elderly individuals