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24 GLP-1 RAs are an antidiabetic class of drugs, but their effect on the relative reduction in HbA1c compared with placebo was moderate (0.41.2%) in the cardiovascular outcomes trials (CVOTs)

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The STEP 4 trial specifically studied what happens when people stop semaglutide after 20 weeks

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In some cases, particularly in very elderly or frail patients, the risks of weight loss may outweigh potential benefits, and weight maintenance or modest weight reduction through less intensive interventions may be more appropriate