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39-41 For example, a particular increase in SOCS3 expression is observed in ARC neurons of mice with diet-induced obesity and this may be a key cause of leptin resistance

Benefits Appetite suppressant Promotes sensation of fullness Can be taken alone, or in combination with GLP1, to promote weight loss Currently in Phase III clinical trial (RENEW2) evaluating its effect on obesity and diabetes as monotherapy Currently in Phase III clinical trial (REDEFINE3) evaluating its effect on cardiovascular health, when combined with Semaglutide Dosing Subcutnaeous 0.6 mg 4.8 mg Once a Week Any time of day SEMAGLUTIDE Synthetic polypeptide

doi: 10.1016/j.cmet.2017.10.009 112 CannonBNedergaardJ