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Although the findings in the CANVAS trial showed a higher risk of amputation when taking canafliglozin compared to placebo [92], no significant difference in the risk of this complication was observed in the CREDENCE study [88]

Most of the time, people are using the word to describe something much more ordinary: staying at a lower dose longer, using the lowest effective dose, or using compounded formulations that require careful measurement and clear instructions

doi: 10.1038/nm727 6 GasbjergLSChristensenMBHartmannBLanngARSparre-UlrichAHGabeMBNet al

When to Seek Immediate Medical Attention Contact your healthcare provider or seek emergency care if you experience: Severe abdominal pain that does not go away Signs of an allergic reaction (rash, swelling, difficulty breathing) Symptoms of pancreatitis (severe abdominal pain, vomiting) Symptoms of severe dehydration (dizziness, confusion, rapid heartbeat) FDA Adverse Event Reporting