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elevated serum creatinine (1.7 mg/dL [0.731.22]) and blood urea nitrogen (90 mg/dL [824]), reflecting dehydration

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Generation of cellular ROS production, decrease in nitric oxide bioavailability, and activation of enzymes like NADPH oxidase, and many signaling factors induce oxidative stress followed by breakdown of redox balance with consequential development of physiological and metabolic disorders, including endothelial dysfunction, inflammation and increasing concentration of VSMCs

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