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Oxidative stress and mitochondrial dysfunction are considered central features of neurodegenerative diseases [26], and the long-term use of KD may positively affect mitochondrial function through several mechanisms

Clioquinol, a therapeutic agent for Alzheimers disease, has proteasome-inhibitory, androgen receptorsuppressing, apoptosis-inducing, and antitumor activities in human prostate cancer cells and xenografts

Cardiac studies show elimination of arrhythmias in rat models and protection against ischemia-reperfusion injury

It may be because of the short treatment course in our study (50 2 days) or continuing of FM medications such as duloxetine or tricyclic antidepressants in the study time which could attenuate the vitamin B12 effect