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362 Uric acid-lowering drugs can be broadly classified into three major groups: drugs that reduce uric acid synthesis (xanthine oxidase inhibitors), drugs that promote uric acid excretion (reabsorption inhibitors), and drugs that regulate uric acid metabolic hydrolysis (uricase inhibitors)

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Clinical studies have demonstrated that retatrutide induces substantial and sustained weight loss, outperforming placebo and certain existing obesity drugs

Mar 2010;24(3):339-345

This is part of why B12 has a strong safety record, and it is also why levels sometimes need regular replenishment during active treatment