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Remember that peptides are a relatively new area of research and clinical use, and the understanding of their safety and efficacy is continually evolving

For instance, Fisher et al.[48] found up to 7-fold differences in the rates of APAP glucoronidation in a sample of 20 human livers, and Court et al.[54] found 15-fold inter-individual variability in APAP glucoronidation rates in liver microsomal fractions

But what does this mean

In terms of electrical remodeling, mitochondrial ROS decrease the activity of L-type Ca 2+ channels, resulting in a shortened action potential duration

10.1016/j.arr.2024.102416 160 WatanabeH.DijkstraJ