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3 Results 3.1 Metabolome analysis reveals dominant impact of SLE on the pentose phosphate pathway, nucleotide, cysteine, and kynurenine metabolism Quantitative enrichment analysis of 258 measured metabolites revealed robust changes in the metabolome of SLE patients PBL relative to those of healthy controls matched for age within 10 years, gender, and ethnic background

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Methylated B12 refers to a form of vitamin B12 that has been chemically altered to include a methyl group, making it more readily absorbed and utilized by the body, especially for those with certain genetic mutations affecting B12 metabolism