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Hypoglycemia Risk: When combined with insulin or medications that cause insulin release, GLP-1 medications can increase hypoglycemia risk
As the upstream RLuc reporter is translated by cap-dependent scanning 58 , which is reported to be enhanced in YBX1 deficiency 59 , to compare the translational efficiency of the PRKAA1 5UTR in shCtrl and shGDH1 or shYBX1 cells, the FLuc activity of the empty reporter group was used for normalization, as previously described 38
The alternative hypothesis offered above, however, is consistent with previous studies that support a role for ligand mobility in activation of other GPCRs
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