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436 This variant causes severe SEL1LHRD1 ERAD dysfunction via disruption of disulfide bond formation within the luminal fibronectin II domain of SEL1L and subsequently causes SEL1L degradation by HRD1

A theoretical pI of 5.8, and net charges of +2.9 and 15.5 at pH 5.5 and pH 7.4, respectively, were calculated for the GLP-1 albumin fusions (Supplementary Fig

This absence reflects the lack of published interaction data rather than a confirmed safety signal

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