Oxidative stress caused by factors such as environmental toxins, physical or emotional stress, strenuous exercise, and illness can lead to tissue damage, DNA damage, inflammation, neuro-degeneration and the development of chronic diseases such as cancer, diabetes, arthritis, stroke, cardiovascular disease, and more
10.1186/s13023-021-01693-9 Orphanet J Rare Dis
Starting low and going slow with dose titration reduces this risk meaningfully
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667 Controlled cortical impact results in increased expression of ACSL4 and ALOX15, as well as ipsilateral cortical GSH consumption, suggesting that the ferroptosis pathway may be a valuable therapeutic target after TBI