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95% CI, 2.52 to 7.86) [73]

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Importantly, their influence extends to skeletal muscle, where GLP-1 RAs promote glucose uptake via the AMP-activated protein kinase pathway, increase vascular blood flow, and mitigate glucotoxicity, thereby supporting muscle protein synthesis and inhibiting catabolic pathways [14, 15]

Research profiles its selectivity for NNMT over other methyltransferases and establishes structure-activity relationships