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Administered weekly, it has shown a significant reduction in body weight for individuals with a BMI of 30 or higher, or 27 or higher with related conditions

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Sensitivity analyses excluding studies with a higher risk of bias yielded pooled effect estimates that remained consistent with the primary analysis, although the confidence intervals widened slightly, suggesting that such studies contributed modest precision without altering the direction or significance of the effect

This protein, designated IRS-2, is immunologically distinct from IRS-1