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10.1038/s41598-025-87341-9 76

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What the Research Suggests Clinical studies and pilot trials evaluating intralesional PRP for Peyronies disease have demonstrated: Favorable safety profiles Potential improvements in curvature and sexual function Reduced plaque density in some patients Some investigational protocols specifically include plaque needling prior to PRP injection , recognizing that mechanical disruption may enhance the effectiveness of regenerative therapies