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This dosing regimen also resulted in effects on growth, with the animals failing to gain weight.31 Both of these effects were prevented by the administration of methionine in the diet leading to the suggestion that both the 5-oxoprolinuria and growth inhibition resulted from a lack of sulfur-containing amino acids due to GSH consumption to detoxify NAPQI, with severe disruption of the gamma -glutamyl cycle

Aging 1 , 11171126 (2021)

Its development code during preclinical characterization was NNC 26-0161

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This THF derivative is required for the synthesis of thymidine which is catalyzed by thymidylate synthetase