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Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells

Stimulation of the epithelium with TNF- led to a marked upregulation of Intercellular Adhesion Molecule 1 (ICAM-1) expression in the ECs within 5 hours, subsequently enhancing the adhesion of fluorescently labeled human neutrophils perfused through the vascular microchannel, which is an inflammatory response characteristic of lung tissue during acute inflammation ( Figures 3B, C )

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