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D'Alessio M, Cerella C, Amici C, Pesce C, Coppola S, Fanelli C, et al

Cocaine acts as a true competitive inhibitor that directly occupies the S1 central substrate site, physically blocking the reuptake of endogenous monoamines

This protruding material can press directly on the spinal cord or, more commonly, on the sensitive nerve roots that exit the spine at each level

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