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All these concepts are elaborately discussed in the paragraphs of this position statement, which represents, in our opinion, a necessary innovative document that shifts the paradigm of simple insulin resistance/deficiency interaction

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Delayed gastric emptying, gastroparesis-like symptoms, intestinal obstruction, biliary disease, and pancreatic safety concerns were variably reported, with heterogeneous and sometimes conflicting evidence across studies

These effects translate to improved tensile strength and elasticity in connective tissue and vasculature, while also supporting visible improvements in skin firmness, density, and texture