Among the extra-pancreatic organs, the lung had the highest level of Glp1r mRNA expression [44, 45]
Life Sci (2015) 126:816.10.1016/j.lfs.2015.01.030 69 SharmaSMellsJEFuPPSaxenaNKAnaniaFA
moreover, it has been reported that GLP-1RA down-regulated AT1 and up-regulated AT2 in cardiomyocytes, glomerular capillaries and proximal tubules of the renal cortex in rats (73, 74, 77), resulting in a protective effect against ANG II-induced cardiac and kidney fibrosis (73, 74, 77)
Semaglutide trials reported 24-29% constipation rates while tirzepatide trials showed 12-27%
We're gonna talk about the combination of GLP one therapy with hormone therapy, and how this may be a clinically synergistic strategy that is backed by emerging evidence