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Vitamin C induces human melanoma A375 cell apoptosis via Bax- and Bcl-2-mediated mitochondrial pathways

In a clinical trial, administration of 2600 mg of ALA to 18 patients just before kidney transplantation along with perfusion of the renal grafts with 600 mg of ALA 1 h before transplantation markedly reduced plasma creatinine level and severity of DGF, and prevented renal allograft rejection while increasing MDRD during the first 14 days after kidney transplantation compared to placebo-treated control group (18 patients) (Weber et al., 2017)

Funding This work was supported by the National Natural Science Foundation of China (No

BPC-157 in Regenerative and Functional Medicine 1