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So its entirely reasonable to ask how drugs that enhance insulin action such as GLP-1 medications like semaglutide or tirzepatide can reduce harmful visceral fat, lower the risk of heart attack and stroke, and possibly even influence long-term cancer risk

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To explore through an alternative strategy whether GLP-1R binding kinetics influence PM recycling and insulin secretion, we utilized the GLP-1R allosteric modulator 4-(3-( b enzyloxy)phenyl)-2-( e thylsulfinyl)-6-( t rifluoro-methyl) p yrimidine (BETP), which alters the residence time of orthosteric GLP-1R agonists 45

Hepatology 41 , 13131321 (2005)