Skin cells take roughly 27 to 30 days to turn over, meaning any internal changes will take at least a month to reach the surface
This bypasses the energy-intensive de novo synthesis pathway
Furthermore, ionomycin, an activator of extracellular traps, significantly increased METs formation, as well as the co-localization of citH3 and MMP12 in macrophages
As in the case of NMOSD, previously seen as another MS phenotype and now largely understood as an astrocytopathy, better comprehension of the mechanisms by which glia relate to neuroinflammatory diseases may arise and reveal completely new aspects of those disorders
Incorporating dietary precursors like sulfur-rich foods (e.g., broccoli, garlic, onions) can help