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96 Specifically, this compound decreases the levels of GSH and superoxide dismutase (SOD), increases malondialdehyde (MDA) levels, promotes E-cadherin expression, and lowers N-cadherin expression, 96 indicating that gambogenic acid can induce ferroptosis to inhibit TGF-1-induced EMT by disrupting the oxidative stress balance of melanocytes

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PLoS ONE 9 , e98972 (2014)

Typically, it's a problem that's found in older and middle or middle-aged cats