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NAD+/NADH ratio assays, SIRT1 activity assays, and mitochondrial respiration measurements (such as oxygen consumption rate via extracellular flux analysis) are standard methods for studying this combination's proposed effects in cell-based models, typically comparing single-compound and combined-compound treatment conditions against untreated controls

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After discussing options for re-initiating treatment, the patient would prefer to be observed in the ED until he reaches a COWS score sufficient to initiate treatment with buprenorphine

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[DOI] [PMC free article] [PubMed] [Google Scholar] 41.Pizzorno J