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pylori -induced gastritis have revealed a strong correlation between gastric cancer risk and DNA methylation ( The inflammatory tumor microenvironment is now recognized as a significant contributor to tumor growth and progression ( 4.4 Limitations of current anti-inflammatory therapies For decades, nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin and ibuprofen have been the cornerstone of managing inflammatory symptoms ( 5 Versatile therapeutic potentials of supersulfide donors in inflammatory diseases Endogenous and synthetic supersulfide donors, as summarized in Figure 9 , can penetrate cells and organs, delivering sulfur atoms to intracellular acceptors, thereby elevating supersulfide levels ( Figure 9 5.1 Prevention of septic shock in mice by suppressing NF-B signaling pathway In the mouse macrophage cell line RAW264.7 cells, stimulation with LPS induced early-phase production of TNF-