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Franco et al., 2007a

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Cohort 2 consisted of patients (not in cohort 1) who received 6 or more intramuscular injections within 1 year and had a laboratory test 2 months before the intramuscular injection claim

Given that the extracellular GSH/GSSG and cysteine/CySS redox pools are under tight regulation during physiologic health (156, 157), these observations reflect a global disturbance in both thiol availability and thiol redox signaling in individuals with severe asthma that likely has important clinical and therapeutic implications

Rather than drawing at random times, experienced researchers draw at the same time on the same days