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To put it in context, nicotinamide has shown signs of liver toxicity only at doses around 3,000 mg per day or higher

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Meng, S

In addition, the pro-oxidant/antioxidant effects of polyphenols and vitamins are context-dependent and moderate doses may be cardioprotective while supraphysiologic levels negatively affect the oxidative state or disrupt ROS-mediated signalling that is important for chemotherapy-induced killing of tumour cells (218)