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Because of global aging, the prevalence of pain, depression, and comorbid pain and depression is expected to increase (Molton and Terrill, 2014

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In the context of hemorrhoidal tissue, TB-4 enhances re-epithelialization (the reformation of the protective mucosal layer) and reduces inflammatory cytokine production via the NF-B pathway

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Therefore, developing peptide epitope vaccine strategies targeting the SARS-CoV-2 S protein may yield a safer vaccine