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These approaches have longer track records and clearer regulatory status even if they may work more slowly or less effectively than peptide therapy

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Long-term testing: Conduct long-term tests under recommended storage conditions to observe changes in the physical and chemical properties of the cream and determine its validity period

A randomized, double-blind, placebo-controlled trial with shift workers suffering from sleep disorders demonstrated that 5 mg melatonin taken before sleep over four weeks significantly improved sleep quality and cognitive performance, with notable reductions in fatigue and good tolerability, supporting the role of melatonin in managing NSW-related sleep issues 189

Therefore, this mini review aims to summarize the current evidence surrounding the effect of urolithin A on biological pathways relevant to sleep health and explore possible mechanisms by which this polyphenolic metabolite could impact sleep, thereby highlighting future opportunities for research