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While metabolic biases differimpaired glycolysis in RA T cells versus enhanced glycolysis in MS and SLEthey converge on a common immunological phenotype: Th17 cell hyperactivation and Treg cell functional impairment ( Figure 2 )

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Thus, in addition to modulating GH release, GHRH indirectly regulates the proliferation of cells in multiple other tissues including tumor cells through a GHRH/GH/IGF-1 axis