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These drugs also act in the brain to reduce hunger and act on the stomach to delay emptying, so you feel full for a longer time

A comprehensive literature search was performed across three databases: PubMed, Scopus, and Web of Science

Effective management requires individualized dose escalation, patient education, and nonpharmacologic strategies

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Common gastrointestinal effects include: Bloating and gas : Increased fermentation activity from probiotic bacteria can produce excess intestinal gas, causing abdominal distension and discomfort Mild diarrhea or loose stools : Changes in gut flora composition may temporarily alter bowel habits Abdominal cramping : Some individuals experience mild to moderate cramping as their digestive system adapts Nausea : Less common but reported, particularly when supplements are taken on an empty stomach These symptoms are generally mild, self-limiting, and often resolve within days to weeks as the microbiome equilibrates