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Palmitoyl Tripeptide-38 is a next-generation peptide shown in research to stimulate key components of the skin matrixincluding collagen I & III, fibronectin, hyaluronic acid, and laminin-5. Its targeted effects help visibly smooth wrinkles, improve firmness, and enhance skins three-dimensional structure

160,161 For example, HM15211, a triple agonist developed by Hanmi Pharmaceutical in South Korea that activates GLP-1R, GIPR and GCGR has entered early clinical trials for the treatment of obesity and non-alcoholic steatohepatitis (NASH)

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