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Description

Mouse tumor-bearing models as preclinical study platforms for Oral squamous cell carcinoma

Neuropsychopharmacology 43 , 627637, (2018)

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Huang, C

Over time, the genome becomes increasingly dysregulated: DNA regions that should be silent become noisy, protective genes are switched off, and chromatin, the scaffold of DNA wrapped around histones (imagine them like packaging bundles), becomes condensed and brittle, losing its flexibility