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Loomba R, et al

While these agents are now recognized for their dual cardiometabolic and renal protective effects, earlier meta-analyses lacked dedicated renal outcome trials to fully assess their efficacy in high-risk CKD/CVD populations

When to Discuss Alternatives with Your Provider If you are on therapeutic-dose semaglutide (1.02.4 mg weekly), adhering consistently, following dietary guidance, maintaining adequate sleep, and have ruled out metabolic or endocrine barriers, yet still experience minimal weight loss after 1216 weeks, it's appropriate to discuss next steps

Few other GIP, GLP-1, and glucagon receptor agonists, e.g., HM15211 and SAR441255, have reached early clinical development